Funding Research. Changing Lives.
The ARCI Initiative is a global nonprofit organization dedicated to improving the lives of people affected by Autosomal Recessive Congenital Ichthyosis (ARCI).
We invest in groundbreaking research that advances new therapies and, at the same time, support initiatives that help bring hope and care to patients and families around the world.
Current Initiatives
Explore the groundbreaking research we're funding, the scientists leading these efforts, and the impact your generosity is making for the future of ARCI.
Gene Therapy for Lamellar Ichthyosis
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The team has developed a novel topical gene therapy that delivers a CRISPR base editor directly to affected skin using lipid nanoparticles. After demonstrating successful gene correction, restoration of skin function, and an excellent safety profile in preclinical studies, the next milestone is manufacturing the therapy under GMP standards and launching the first clinical trial in patients with ARCI.
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The project is led by Prof. Sarah Hedtrich and a multidisciplinary team of experts in gene therapy, lipid nanoparticle delivery, skin biology, and clinical development. Supported by internationally recognized advisors, the team combines scientific excellence with the experience needed to bring this therapy from the laboratory to patients.
Prof. Dr. Sarah Hedtrich
Pioneer in Skin Gene Therapy & 3D Tissue Engineering
Dr. Friedrich Hedtrich
Seasoned Business Leader with 15+ Years Experience Scaling Organizations
Dr. Gaurav Sadhnani
LNP Formulation & Drug Delivery Specialist
Elena Lizunova
Disease Modeling & Preclinical Development Expert
Initiative pending…
Initiative Funding:
The Global Access Initiative
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Millat Sahara Foundation is a humanitarian nonprofit with extensive experience delivering healthcare, education, and community support in underserved regions of Pakistan and Afghanistan. By combining their local expertise and trusted community networks with our focus on rare genetic skin diseases, we can reach patients who might otherwise never receive the care and support they need.
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Through our partnership with Millat Sahara Foundation, we support underserved communities in Pakistan and Afghanistan by improving access to healthcare, education, and essential resources. Together, we work to raise awareness of rare genetic skin diseases, strengthen local support, and improve the quality of life for children and families living with ARCI.
